Hydrochloric Acid → (4-Bromo-benzyloxy)-acetaldehyde
반응식
Cl.[Br:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][O:10][CH2:11][CH:12](OCC)[O:13]CC)=[CH:5][CH:4]=1>C(OCC)C.[Cl-].[Na+].O>[Br:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][O:10][CH2:11][CH:12]=[O:13])=[CH:7][CH:8]=1참가 물질
5
실험 절차
5 N HCl (20 mL) is added to a stirred solution of 1-bromo 4-(2,2-diethoxy-ethoxymethyl)-benzene (1.86 g, 6.13 mmol) in diethyl ether (20 mL) at ambient temperature. The resultant two-layered mixture is stirred vigorously under nitrogen for 16 hours. Diethyl ether (30 mL) and brine (20 mL) are added to the mixture. The organic layer is separated, washed with half-saturated brine, dried, filter and concentrated into a ˜50 mL solution (35 mg/mL). 1H NMR (CDCl3): δ9.72 (s, 1H), 7.49 (d, J=7.49 Hz, 2H), 7.24 (d, J=7.9 Hz, 2H), 4.57 (s, 2H), 4.11 (s, 2H).
후처리
- customThe organic layer is separated
- washwashed with half-saturated brine
- customdried
- filtrationfilter
- concentrationconcentrated into a ˜50 mL solution (35 mg/mL)
출처 및 근거
- ORD 기록
- ord-ddb3da2065374c6896e42bddf45ceebd
- 출처 데이터셋
- uspto-grants-2008_08
- 특허 번호
- US07414063B2
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