Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → ((4-Cyclohexylphenoxy)methyl)oxirane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 4-Cyclohexylphenol | HCID 14327 | — |
| 반응물 | (-)-Epichlorohydrin | HCID 2734062 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | ((4-Cyclohexylphenoxy)methyl)oxirane | HCID 5743581 | — |
반응 단계
To a mixture of R-epichlorohydrin (9.8 g, 106 mmol) and 4-cyclohexylphenol (3.73 g, 21.2 mmol) in acetonitrile (40 ml) was added cesium carbonate (6.9 g, 21.2 mmol). The mixture was heated at reflux for 3 hours. The reaction mixture was cooled, poured into water (100 mL) and extracted twice with EtOAc. The organic phases were combined and washed with water, brine, dried (Na2SO4), concentrated and dried under high vacuum overnight to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08207181B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-d3037173a1b8480bbbcf4512227dd842 |
| 출처 메모 | uspto-grants-2012_06 |