3-Aminopyridine → 6-Methyl-3-(pyridin-3-ylamino)-pyridine-2-carboxylic acid ethyl ester

HRID 2219576노트

반응식

HRID 2219576 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:11](Br)=[CH:10][CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:5])[CH3:2].[NH2:14][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1>[Pd]>[CH2:1]([O:3][C:4]([C:6]1[C:11]([NH:14][C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[CH:10][CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 100093-AminopyridineHCID 69237506Ethyl 3-bromo-6-methylpicolinate

생성물 1

HCID 692372146-Methyl-3-(pyridin-3-ylamino)-pyridine-2-carboxylic acid ethyl ester

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

The Pd catalyzed coupling of 3-Bromo-6-methyl-pyridine-2-carboxylic acid ethyl ester and 3-Amino-pyridine was performed in accordance with the general method of Example 78, step 3 to yield the title compound as a light yellow crystalline solid, MS (ISP): m/e=258.1 (M+H+).

출처 및 근거

ORD 기록
ord-f939f373b0384a4788082d4e90acb1c3
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07414060B2

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