1,2-Dichloroethane → N'-(2-hydroxy-3-phenylpyrido[2,3-b]pyrazin-6-yl)nicotinohydrazide

HRID 221987노트

반응식

HRID 221987 반응식
[NH:1]([C:3]1[CH:4]=[CH:5][C:6]2[C:7]([N:19]=1)=[N:8][C:9]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[C:10]([OH:12])[N:11]=2)[NH2:2].[C:20](O)(=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[N:23][CH:22]=1.C(Cl)CCl.O>CN1C(=O)CCC1>[OH:12][C:10]1[N:11]=[C:6]2[CH:5]=[CH:4][C:3]([NH:1][NH:2][C:20](=[O:27])[C:21]3[CH:26]=[CH:25][CH:24]=[N:23][CH:22]=3)=[N:19][C:7]2=[N:8][C:9]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

6

반응물 4

HCID 111,2-DichloroethaneHCID 938Nicotinic AcidHCID 962WaterHCID 178514300HCID 178514300, 화합물

생성물 1

HCID 178523945N'-(2-hydroxy-3-phenylpyrido[2,3-b]pyrazin-6-yl)nicotinohydrazide

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

To a mixture of 6-hydrazino-3-phenylpyrido[2,3-b]pyrazin-2-ol (3-3) (3.7 g, 14.5 mmol) and nicotinic acid (2.1 g, 17.4 mmol) in NMP (50 mL) was added EDC (3.1 g, 16.0 mmol), and stirred at room temperature for overnight. To the mixture was added water, and the resulting solid was collected by filtration to yield N-(2-hydroxy-3-phenylpyrido[2,3-b]pyrazin-6-yl)nicotinohydrazide (3-4).

후처리

  1. filtrationthe resulting solid was collected by filtration

출처 및 근거

ORD 기록
ord-2b5411ef05394b8583677cc249f58a3a
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207169B2

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