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Water → 1-[1-(2-fluoroethyl)-1H-pyrazol-4-yl]-2-[3-(2-fluoropyridin-3-yl)phenyl]ethane-1,2-dione

HRID 2220450
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HRID 2220450 반응식
[F:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]#[C:15][C:16]3[CH:17]=[N:18][N:19]([CH2:21][CH2:22][F:23])[CH:20]=3)[CH:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.C([O-])(O)=[O:25].[Na+].[O-]S([O-])(=O)=O.[Mg+2].[Mn]([O-])(=O)(=O)=O.[K+].[OH2:41]>CC(C)=O>[F:23][CH2:22][CH2:21][N:19]1[CH:20]=[C:16]([C:15](=[O:25])[C:14]([C:10]2[CH:11]=[CH:12][CH:13]=[C:8]([C:7]3[C:2]([F:1])=[N:3][CH:4]=[CH:5][CH:6]=3)[CH:9]=2)=[O:41])[CH:17]=[N:18]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 5

HCID 962WaterHCID 24083Sulfuric acid magnesium salt (1:1)HCID 516875Potassium PermanganateHCID 516892Sodium BicarbonateHCID 597726592-fluoro-3-(3-{[1-(2-fluoroethyl)-1H-pyrazol-4-yl]ethynyl}phenyl)pyridine

생성물 1

HCID 687019131-[1-(2-fluoroethyl)-1H-pyrazol-4-yl]-2-[3-(2-fluoropyridin-3-yl)phenyl]ethane-1,2-dione
수율 62%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 2-fluoro-3-(3-{[1-(2-fluoroethyl)-1H-pyrazol-4-yl]ethynyl}phenyl)pyridine (140 mg, 0.45 mmol) in acetone (7 mL) is added a warm (−40° C.) solution of NaHCO3 (23 mg, 0.27 mmol) and MgSO4 (82 mg, 0.68 mmol) in H2O (7 mL) followed by the addition of solid potassium permanganate (156 mg, 0.99 mmol) in one portion. After stirring at room temperature for 30 minutes, the reaction mixture is extracted with Et2O/hexane (1/1) until no product left in aqueous layer. The combined organic extracts are dried (MgSO4) and concentrated to dryness to afford 1-[1-(2-fluoroethyl)-1H-pyrazol-4-yl]-2-[3-(2-fluoropyridin-3-yl)phenyl]ethane-1,2-dione (95 mg, 62%) as an oil. MS (+) ES: 342 (M+H)+.

후처리

  1. extractionthe reaction mixture is extracted with Et2O/hexane (1/1) until no product
  2. waitleft in aqueous layer
  3. dry with materialThe combined organic extracts are dried (MgSO4)
  4. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-9a33f42b598145cea56845f605f32165
출처 데이터셋
uspto-grants-2008_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07417047B2

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