Water → Ethyl (4-bromo-2,6-dimethylphenoxy)acetate

HRID 2220630

반응식

HRID 2220630 반응식
Br[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[Br:8][C:9]1[CH:14]=[C:13]([CH3:15])[C:12]([OH:16])=[C:11]([CH3:17])[CH:10]=1.C([O-])(=O)C.[K+].O>CN(C)C=O.C(OCC)(=O)C>[CH2:6]([O:5][C:3](=[O:4])[CH2:2][O:16][C:12]1[C:13]([CH3:15])=[CH:14][C:9]([Br:8])=[CH:10][C:11]=1[CH3:17])[CH3:7]

참가 물질

7

반응물 4

HCID 962WaterHCID 7748Ethyl bromoacetateHCID 169194-Bromo-2,6-dimethylphenolHCID 517044Potassium Acetate

생성물 1

HCID 875019Ethyl (4-bromo-2,6-dimethylphenoxy)acetate

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

반응 조건

온도
80 °C

실험 절차

Ethyl bromoacetate (0.662 mL) was added to a mixture of 4-bromo-2,6-dimethylphenol (1.0 g) and potassium acetate (1.031 g) in N,N-dimethylformamide (10 mL), and the mixture was stirred at 80° C. for 3 hrs. Water and ethyl acetate were added to the reaction mixture. The organic layer was separated, washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/10) to afford the title compound (1.29 g).

후처리

  1. customThe organic layer was separated
  2. washwashed with water and brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure
  5. customthe residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/10)

출처 및 근거

ORD 기록
ord-25ea414057584b038524dd258874c7e8
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07417169B2

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