Lithium Hydroxide → Benzoic Acid

HRID 2220732노트

반응식

HRID 2220732 반응식
C[O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1CSC1C=CC=C2C=1N=CC=C2.[Li+].[OH-]>CO.O>[C:3]([OH:22])(=[O:2])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 59773474HCID 59773474, 화합물

생성물 1

HCID 243Benzoic Acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of 1.0 eq of ester 41 and 3.0 eq. of LiOH in methanol and water was heated to 65° C. for a time sufficient for completion of the hydrolysis. The mixture was cooled to room temperature and concentrated, then diluted with H2O. The pH of the aqueous mixture was adjusted to 4.5 and extracted with EtOAc. The organic layer was washed with brine and dried over Na2SO4, filtered, and concentrated to give the intermediate benzoic acid.

후처리

  1. concentrationconcentrated
  2. additiondiluted with H2O
  3. extractionextracted with EtOAc
  4. washThe organic layer was washed with brine
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ec22f5c9214a43ce9452d43aec77d015
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07417152B2

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