Potassium Acetate → 5H,6H,7H,8H,9H-pyrido(3,2-b)azepin-6-one

HRID 2220745노트

반응식

HRID 2220745 반응식
CC1C=CC(S(O[N:12]=[C:13]2[CH2:22][CH2:21][CH2:20][C:19]3[N:18]=[CH:17][CH:16]=[CH:15][C:14]2=3)(=O)=O)=CC=1.C([O-])(=[O:25])C.[K+]>CCO.O>[N:18]1[C:19]2[CH2:20][CH2:21][CH2:22][C:13](=[O:25])[NH:12][C:14]=2[CH:15]=[CH:16][CH:17]=1

참가 물질

5

반응물 2

HCID 517044Potassium AcetateHCID 85948845HCID 85948845, 화합물

생성물 1

HCID 122830325H,6H,7H,8H,9H-pyrido(3,2-b)azepin-6-one

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A mixture of 1.0 eq of 95 and 2.3 eq of potassium acetate in 70 mL of EtOH and 140 mL of H2O was refluxed for 17 hrs. After cooling to rt and rotary evaporation of the EtOH, the solution was made alkaline with 10 N NaOH. The mixture was extracted with chloroform (3×50 mL). The combined organic extracts were dried over MgSO4 and vacuum filtered. The filtrate was rotary evaporated and dried under vacuum to yield 96.

후처리

  1. temperaturewas refluxed for 17 hrs
  2. customrotary evaporation of the EtOH
  3. extractionThe mixture was extracted with chloroform (3×50 mL)
  4. dry with materialThe combined organic extracts were dried over MgSO4 and vacuum
  5. filtrationfiltered
  6. customThe filtrate was rotary evaporated
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-1274ecf09d6440cdb06d900122c2621f
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07417152B2

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