2-Pyrrolidone → HCID 69215404, 화합물

HRID 2221366노트

반응식

HRID 2221366 반응식
Cl[CH2:2][Si:3]([O:6][CH3:7])([CH3:5])[CH3:4].[O-:8][C:9]#[N:10].[K+].[NH:12]1[CH2:16][CH2:15][CH2:14][C:13]1=[O:17]>CN(C=O)C>[CH3:7][O:6][Si:3]([CH2:2][NH:10][C:9]([N:12]1[CH2:16][CH2:15][CH2:14][C:13]1=[O:17])=[O:8])([CH3:5])[CH3:4]

참가 물질

5

반응물 3

HCID 120252-PyrrolidoneHCID 560623(Chloromethyl)methoxydimethylsilaneHCID 11378442Potassium cyanate

생성물 1

HCID 69215404HCID 69215404, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
130 °C

실험 절차

A mixture of 69.3 g of (chloromethyl)methoxydimethyl-silane, 40.6 g of potassium cyanate and 42.6 g of 2-pyrrolidinone in 150 ml of anhydrous DMF was heated at 130° C. with stirring for 5 h. The solvent was then removed under reduced pressure. This gave N-[(methoxydimethylsilyl)methyl]-2-oxo-1-pyrrolidinecarboxamide in quantitative yield with a purity of >90% (analysis by 1H NMR, see Example 2a).

후처리

  1. customThe solvent was then removed under reduced pressure

출처 및 근거

ORD 기록
ord-40873512c0c041d4b579c07ef7f793aa
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07368586B2

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