Hydrochloric Acid → HCID 178437612, 화합물

HRID 2221672노트

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HRID 2221672 반응식
[CH2:1]([C:3]1[S:4][CH:5]=[C:6](/[CH:8]=[CH:9]/[C:10]2[C:11]([O:21]COC)=[N:12][N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:14]=2)[N:7]=1)[CH3:2].Cl>CO>[CH2:1]([C:3]1[S:4][CH:5]=[C:6](/[CH:8]=[CH:9]/[C:10]2[C:11]([OH:21])=[N:12][N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:14]=2)[N:7]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 23076449HCID 23076449, 화합물

생성물 1

HCID 178437612HCID 178437612, 화합물수율 106.9%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
50 °C

실험 절차

To a solution of 2-ethyl-4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-1,3-thiazole (4.49 g) in methanol (50 mL) was added concentrated hydrochloric acid (2.17 mL) at room temperature, and the mixture was stirred at 50° C. for 1 hr. The reaction mixture was evaporated under reduced pressure and the residue was washed with ethyl acetate-diethyl ether to give 4-[(E)-2-(2-ethyl-1,3-thiazol-4-yl)ethenyl]-1-phenyl-1H-pyrazol-3-ol (4.18 g, yield 95%) as orange crystals. hydrochloride. melting point: 222-224° C.

후처리

  1. customThe reaction mixture was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate-diethyl ether

출처 및 근거

ORD 기록
ord-b32f88bf1b824f78903529b1bec2c9ae
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07368578B2

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