3-Chloro-2-nitrobenzoic acid → N-(diethylphosphonomethyl)-2-nitro-3-chlorobenzamide

HRID 2222111

반응식

HRID 2222111 반응식
[Cl:1][C:2]1[C:3]([N+:11]([O-:13])=[O:12])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=O.[PH:14]1(=[O:23])[O:21][CH2:20][CH2:19]C(N)[CH2:17][CH2:16][O:15]1.[CH:24]([N:27](C(C)C)CC)(C)C>ClCCl>[CH2:20]([O:21][P:14]([CH2:24][NH:27][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][CH:10]=[C:2]([Cl:1])[C:3]=1[N+:11]([O-:13])=[O:12])([O:15][CH2:16][CH3:17])=[O:23])[CH3:19]

참가 물질

5

반응물 3

HCID 209023-Chloro-2-nitrobenzoic acidHCID 81531DiisopropylethylamineHCID 178507970HCID 178507970, 화합물

생성물 1

HCID 57457785N-(diethylphosphonomethyl)-2-nitro-3-chlorobenzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 3-chloro-2-nitrobenzoic acid (1 mmol) and aminomethylenediethyl phosphonate (1.1 mmol) in dichloromethane (5 mL) was added diisopropylethylamine (5 mmol) followed by pyBOP (1.5 mmol). The reaction was stirred at room temperature for 3 h and concentrated. The mixture was purified by chromatography to yield N-(diethylphosphonomethyl)-2-nitro-3-chlorobenzamide as a solid.

후처리

  1. concentrationconcentrated
  2. customThe mixture was purified by chromatography

출처 및 근거

ORD 기록
ord-b600187e708946b089bdc25769d32996
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07371739B2

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