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Ethyl chloroacetate → ethyl [4-[(Z)-2-cyano-2-(3,4-dimethoxy-phenyl)-vinyl]-phenoxy]-acetate

HRID 2222356
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HRID 2222356 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5](/[C:11](=[CH:14]/[C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)/[C:12]#[N:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:12](/[C:11](/[C:5]1[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)=[CH:14]\[C:15]1[CH:16]=[CH:17][C:18]([O:21][CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:19][CH:20]=1)#[N:13]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 7751Ethyl chloroacetateHCID 11430Potassium CarbonateHCID 10446442(Z)-2-(3,4-dimethoxyphenyl)-3-(4-hydroxyphenyl)acrylonitrile

생성물 1

HCID 10384323ethyl [4-[(Z)-2-cyano-2-(3,4-dimethoxy-phenyl)-vinyl]-phenoxy]-acetate수율 34%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Compound 1 (281 mg) and ethyl chloroacetate (245 mg) were dissolved in acetone, and potassium carbonate was added to the resultant solution, followed by reflux for three hours. The resultant mixture was subjected to filtration, and insoluble matter was removed from the mixture. The resultant filtrate was concentrated to dryness under reduced pressure, followed by recrystallization, to thereby produce the target product (124 mg, yield: 34%).

후처리

  1. temperatureby reflux for three hours
  2. filtrationThe resultant mixture was subjected to filtration, and insoluble matter
  3. customwas removed from the mixture
  4. concentrationThe resultant filtrate was concentrated to dryness under reduced pressure
  5. customfollowed by recrystallization

출처 및 근거

ORD 기록
ord-2102ffc89b3b428fb6e9eec6dc6fcac6
출처 데이터셋
uspto-grants-2008_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07371773B2

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