Diisopropylethylamine → HCID 178462095, 화합물

HRID 2222467노트

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HRID 2222467 반응식
[N:1]1([C:8]2[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=2)[CH2:6][CH2:5][O:4][CH2:3][C:2]1=[O:7].CCN(C(C)C)C(C)C.Cl.[Cl:27][C:28]1[CH:39]=[CH:38][C:31]2[NH:32][C:33]([C@@H:35]([NH2:37])[CH3:36])=[N:34][C:30]=2[CH:29]=1>CN(C=O)C>[Cl:27][C:28]1[CH:39]=[CH:38][C:31]2[NH:32][C:33]([C@@H:35]([NH:37][C:12](=[O:14])[C:11]3[CH:10]=[CH:9][C:8]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][C:2]4=[O:7])=[CH:16][CH:15]=3)[CH3:36])=[N:34][C:30]=2[CH:29]=1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 230877894-(3-Oxomorpholino)benzoic acidHCID 178461860(1S)-1-(5-chloro-1h-benzimidazol-2-yl)-ethylamine-hydrochloride

생성물 1

HCID 178462095HCID 178462095, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

254 mg (1.15 mmol) 4-(morpholin-3-on-4-yl)-benzoic acid (prepared by synthesis sequence analogously to Example 30a, 2d and 21a) are placed in 5 ml DMF and 428 mg (1.0 mmol) PfTU and 514 μl (3.0 mmol) DIPEA are added. After stirring at ambient temperature for 10 minutes 232 mg (1.0 mmol) (1S)-1-(5-chloro-1H-benzimidazol-2-yl)-ethylamine-hydrochloride are added and the mixture is stirred for 16 hours at ambient temperature. Then the reaction mixture is filtered through basic aluminium oxide and evaporated down i. vac. The residue is purified by chromatography on silica gel (eluting gradient: dichloromethane/methanol 100:0->90:10), the corresponding fractions are evaporated down i. vac., the residue is dissolved in acetonitrile/water and lyophilised.

후처리

  1. additionare added
  2. filtrationThen the reaction mixture is filtered through basic aluminium oxide
  3. customevaporated down i
  4. customThe residue is purified by chromatography on silica gel (eluting gradient: dichloromethane/methanol 100:0->90:10)
  5. customthe corresponding fractions are evaporated down i
  6. dissolution, the residue is dissolved in acetonitrile/water

출처 및 근거

ORD 기록
ord-b778ffedc7004edeb61d24141f0471c8
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07371743B2

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