Water → 2-Amino-1,3-thiazole-4-carboxylic acid, N-BOC protected

HRID 2222986노트

반응식

HRID 2222986 반응식
C[O:2][C:3]([C:5]1[N:6]=[C:7]([NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[S:8][CH:9]=1)=[O:4].O.O.[OH-].[Li+]>O1CCCC1>[C:14]([O:13][C:11]([NH:10][C:7]1[S:8][CH:9]=[C:5]([C:3]([OH:4])=[O:2])[N:6]=1)=[O:12])([CH3:17])([CH3:15])[CH3:16]

참가 물질

5

반응물 3

HCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 7213137Methyl 2-Boc-aminothiazole-4-carboxylate

생성물 1

HCID 15020512-Amino-1,3-thiazole-4-carboxylic acid, N-BOC protected수율 71%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-tert-Butoxycarbonylamino-thiazole-4-carboxylic acid methyl ester (15.5 g, 60.01 mmol) was dissolved in 4:1 tetrahydrofuran:water (300 mL) followed by the addition of lithium hydroxide monohydrate (5.29 g, 126.07 mmol). The solution was stirred overnight at room temperature. Tetrahydrofuran was removed under vacuum and the salt was neutralized with 2.0 N aqueous hydrochloric acid. The resulting precipitate was filtered and dried to give 2-tert-butoxycarbonylamino-thiazole-4-carboxylic acid (10.4 g, 71%).

후처리

  1. customTetrahydrofuran was removed under vacuum
  2. filtrationThe resulting precipitate was filtered
  3. customdried

출처 및 근거

ORD 기록
ord-2e6ade06a8bf4b1e972ddff4a545d660
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07371869B2

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