Sodium Hydroxide → 1-(3,4-dichlorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][N:10]2[CH:14]=[C:13]([C:15]([O:17]CC)=[O:16])[N:12]=[N:11]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][N:10]2[CH:14]=[C:13]([C:15]([OH:17])=[O:16])[N:12]=[N:11]2)[CH:5]=[CH:6][C:7]=1[Cl:8]참가 물질
4
실험 절차
A solution of ethyl 1-[(3,4-dichlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylate (Intermediate 10) (1.5 g, 5 mmol) and a 1N NaOH solution (7.5 mL, 1.5 eq) in ethanol (50 mL) was stirred at reflux for 48 hours. The solvent was evaporated and the residue was acidified with a 1N HCl solution (15 mL). The precipitate formed was filtered, washed with water and dried to give the title compound as a white solid (1.25 g, 92%). LC/MS: m/z 272 (M+H)+. Rt: 2.05 min.
후처리
- temperatureat reflux for 48 hours
- customThe solvent was evaporated
- customThe precipitate formed
- filtrationwas filtered
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-c5ccb9ba77314d1782006b9b322d8b21
- 출처 데이터셋
- uspto-grants-2012_06
- 특허 번호
- US08207204B2
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