Trifluoroacetic acid → 2-(4-Benzylpiperidin-1-yl)ethan-1-amine

HRID 2223711

반응식

HRID 2223711 반응식
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][CH:13]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:12][CH2:11]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)(Cl)Cl>[CH2:16]([CH:13]1[CH2:12][CH2:11][N:10]([CH2:9][CH2:8][NH2:7])[CH2:15][CH2:14]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 59715914[2-(4-Benzyl-piperidin-1-yl)-ethyl]-carbamic acid tert-butyl ester

생성물 1

HCID 27798312-(4-Benzylpiperidin-1-yl)ethan-1-amine

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

[2-(4-Benzyl-piperidin-1-yl)-ethyl]-carbamic acid tert-butyl ester (1.34 g, 4.2 mmol) is dissolved in CHCl3 (3 mL) and treated with TFA (3 mL) for 2 h at 20° C. The solvent is evaporated, the residue dissolved CH2Cl2 (100 mL) and washed with 1M aqueous NaOH (2×30 mL). The organic layer is dried (Na2SO4), filtered and concentrated to provide the title compound.

후처리

  1. customThe solvent is evaporated
  2. dissolutionthe residue dissolved CH2Cl2 (100 mL)
  3. washwashed with 1M aqueous NaOH (2×30 mL)
  4. dry with materialThe organic layer is dried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-613c097532794b6eb35e701bbccad6b1
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07375227B2

연결된 노트

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