Hydrochloric Acid → Ethyl 4-benzylpiperidine-4-carboxylate

HRID 2223733노트

반응식

HRID 2223733 반응식
[CH2:1]([O:3][C:4]([C:6]1([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:11][CH2:10][N:9](CC2C=CC=CC=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].Cl>CO.[Pd]>[CH2:1]([O:3][C:4]([C:6]1([CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]1)=[O:5])[CH3:2]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 104971761,4-dibenzyl-piperidine-4-carboxylic acid ethyl ester

생성물 1

HCID 53297794Ethyl 4-benzylpiperidine-4-carboxylate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

1,4-Dibenzyl-piperidine-4-carboxylic acid ethyl ester (11.8 g, 35 mmol) is dissolved in MeOH (200 mL) and 1M aqueous HCl (40 mL) and Pd—C (10%, 1 g) are added. The mixture is hydrogenated (7 bar, 70° C.) for 15 h. The catalyst is filtered off and the solvent evaporated to provide the title compound.

후처리

  1. custom(7 bar, 70° C.)
  2. customfor 15 h
  3. filtrationThe catalyst is filtered off
  4. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-eb90651c179e44b0bc1a477ea7437030
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07375227B2

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