1-(2-Amino-ethyl)-4-benzyl-piperidine-4-carboxylic acid ethyl ester → 1-(2-Amino-ethyl)-4-benzyl-piperidine-4-carboxylic acid

HRID 2223737노트

반응식

HRID 2223737 반응식
C([O:3][C:4]([C:6]1([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][NH2:14])[CH2:8][CH2:7]1)=[O:5])C>Cl>[NH2:14][CH2:13][CH2:12][N:9]1[CH2:10][CH2:11][C:6]([CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)([C:4]([OH:5])=[O:3])[CH2:7][CH2:8]1

참가 물질

3

반응물 1

HCID 597159211-(2-Amino-ethyl)-4-benzyl-piperidine-4-carboxylic acid ethyl ester

생성물 1

HCID 179565961-(2-Amino-ethyl)-4-benzyl-piperidine-4-carboxylic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
90 °C

실험 절차

1-(2-Amino-ethyl)-4-benzyl-piperidine-4-carboxylic acid ethyl ester (2.5 g, 10 mmol) is dissolved in 6N aqueous HCl (40 mL) and the mixture heated at 90° C. for 96 h. The reaction mixture is evaporated to provide the title compound as hydrochloride salt.

후처리

  1. customThe reaction mixture is evaporated

출처 및 근거

ORD 기록
ord-d2c8692158c64358a6ab7f4131cc321b
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07375227B2

반응 노트

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