Sodium Hydroxide → 2-Oxo-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

HRID 2225322노트

반응식

HRID 2225322 반응식
[C:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](=[O:14])[NH:9]2)([OH:3])=[O:2].[OH-].[Na+].[H][H]>O.[Pt].[C]>[C:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH2:6][CH2:7][C:8](=[O:14])[NH:9]2)([OH:3])=[O:2]

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 132429962-Hydroxyquinoline-5-carboxylic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 132430022-Oxo-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

시약·촉매·용매 2

HCID 178503042HCID 178503042, 화합물촉매HCID 962Water용매

실험 절차

2 Grams of 5-carboxycarbostyril was suspended in 30 ml of water, then 10N-sodium hydroxide aqueous solution was added to dissolve the crystals. To this solution was added 500 mg of 10% platinum-carbon and this mixture was catalytically reduced with hydrogen gas under condition of 3-4 kg/cm2 at 70° C. After the completion of the reaction, the catalyst was removed from the reaction mixture by filtration, then the pH of the filtrate was adjusted to about pH=1 by adding concentrated hydrochloric acid. The precipitated crystals were collected by filtration, recrystallized from methanol to obtain 820 mg of 5-carboxy-3,4-dihydrocarbostyril in the form of colorless needle-like crystals.

후처리

  1. dissolutionto dissolve the crystals
  2. customAfter the completion of the reaction
  3. customthe catalyst was removed from the reaction mixture by filtration
  4. additionby adding concentrated hydrochloric acid
  5. filtrationThe precipitated crystals were collected by filtration
  6. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-56ee0a7502ab48a29cda7e4ea5f229ca
출처 데이터셋
uspto-grants-1994_09
특허 번호
USRE034722

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