Sodium Hydroxide → HCID 19004073, 화합물

HRID 2225371노트

반응식

HRID 2225371 반응식
[OH-].[Na+].[CH:3]1[C:13]2[CH2:12][C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[C:9]([N:18]3[CH2:23][CH2:22][N:21]([CH2:24][C:25]([O:27]CC)=[O:26])[CH2:20][CH2:19]3)=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1>CO>[CH:3]1[C:13]2[CH2:12][C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[C:9]([N:18]3[CH2:19][CH2:20][N:21]([CH2:24][C:25]([OH:27])=[O:26])[CH2:22][CH2:23]3)=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 19004087HCID 19004087, 화합물

생성물 1

HCID 19004073HCID 19004073, 화합물수율 63.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2N Aqueous sodium hydroxide solution (5 ml) was added to a solution of 1.82 g of ethyl 4-(11H-dibenz[b,e]azepin-6-yl)-1-piperazineacetate in 18 ml of methanol. The solution was refluxed for 30 min and then concentrated. The residue was dissolved in hot water and the solution was neutralized with 0.5N hydrochloric acid. The precipitates were collected by filtration to give 1.06 g of colorless crystals, which were recrystallized from ethanol to give colorless granules, mp 181°-183° C. (decomp.).

후처리

  1. temperatureThe solution was refluxed for 30 min
  2. concentrationconcentrated
  3. dissolutionThe residue was dissolved in hot water
  4. filtrationThe precipitates were collected by filtration

출처 및 근거

ORD 기록
ord-b6a08c05d4ed4dcca12e13a5b65b608c
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05344828

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