1-Azidomethyl-4-methyl-2-oxabicyclo[2.2.2]octan-3-one → 1-Aminomethyl-4-methyl-2-oxabicyclo[2.2.2]-octan-3-one

HRID 2225490노트

반응식

HRID 2225490 반응식
[N:1]([CH2:4][C:5]12[CH2:12][CH2:11][C:8]([CH3:13])([CH2:9][CH2:10]1)[C:7](=[O:14])[O:6]2)=[N+]=[N-].[H][H]>C(O)C.[Pt](=O)=O>[NH2:1][CH2:4][C:5]12[CH2:12][CH2:11][C:8]([CH3:13])([CH2:9][CH2:10]1)[C:7](=[O:14])[O:6]2

참가 물질

5

반응물 2

HCID 190047971-Azidomethyl-4-methyl-2-oxabicyclo[2.2.2]octan-3-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 190047031-Aminomethyl-4-methyl-2-oxabicyclo[2.2.2]-octan-3-one수율 84.6%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매

실험 절차

0.025 g of platinum dioxide was added to a solution of 0.6 g of 1-azidomethyl-4-methyl-2-oxabicyclo[2.2.2]octan-3-one (Example 29) in 30 ml of ethanol. The resultant solution was reacted for 14 hours under 3.5 atom hydrogen gas. After reaction, the catalyst was filtered out, and the solvent was removed in vacuo from the filtrate. As a result, 0.44 g of 1-aminomethyl-4-methyl-2-oxabicyclo[2.2.2]-octan-3-one was obtained as a pale yellow oil, which had the following physiochemical properties:

후처리

  1. customAfter reaction
  2. filtrationthe catalyst was filtered out
  3. customthe solvent was removed in vacuo from the filtrate

출처 및 근거

ORD 기록
ord-651ea7f3fdfc4619b4c7a8a05981a4ef
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05344845

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