HCID 53850434, 화합물 → HCID 19004409, 화합물

HRID 2225647노트

반응식

HRID 2225647 반응식
C[O:2][C:3](=[O:23])[C:4](=[O:22])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[F:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[O:14][CH2:13][CH2:12][O:11][C:8]1[CH:7]=[CH:6][C:5]([C:4](=[O:22])[C:3]([OH:23])=[O:2])=[CH:10][CH:9]=1

참가 물질

4

반응물 1

HCID 53850434HCID 53850434, 화합물

생성물 1

HCID 19004409HCID 19004409, 화합물수율 95.9%

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

실험 절차

A mixture of 4-[[2-(2-fiuorophenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.6 g) in methanol (20 mL) and 0.5N sodium hydroxide (8 mL) was treated as in Example 19. Extraction provided solids which were crystallized from diethyl ether-hexane to give 0.55 g of colorless 4-[[2-(2-fluorophenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid, mp 108°-110° C.

후처리

  1. additionwas treated as in Example 19
  2. extractionExtraction
  3. customprovided solids which
  4. customwere crystallized from diethyl ether-hexane

출처 및 근거

ORD 기록
ord-e4482143d83d471db0026b064389855f
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05344843

반응 노트

불러오는 중…