4-[[2-(Cyclohexyloxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester → 4-[[2-(Cyclohexyloxy)ethyl]oxy]-alphaoxobenzeneacetic acid

HRID 2225700노트

반응식

HRID 2225700 반응식
C[O:2][C:3](=[O:22])[C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][O:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[CH:15]1([O:14][CH2:13][CH2:12][O:11][C:8]2[CH:7]=[CH:6][C:5]([C:4](=[O:21])[C:3]([OH:22])=[O:2])=[CH:10][CH:9]=2)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1

참가 물질

4

반응물 1

HCID 543210414-[[2-(Cyclohexyloxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester

생성물 1

HCID 190043524-[[2-(Cyclohexyloxy)ethyl]oxy]-alphaoxobenzeneacetic acid수율 89.8%

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

실험 절차

A mixture of 4-[[2-(cyclohexyloxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.7 g) in methanol (10 mL) and 0.5N sodium hydroxide (7 mL) was treated as in Example 19. Extraction with diethyl ether provided material which was crystallized from diethyl ether-hexane to give 0.6 g of colorless 4-[[2-(cyclohexyloxy)ethyl]oxy]-alphaoxobenzeneacetic acid, mp 96°-98° C.

후처리

  1. additionwas treated as in Example 19
  2. extractionExtraction with diethyl ether provided material which
  3. customwas crystallized from diethyl ether-hexane

출처 및 근거

ORD 기록
ord-90b957c3af2c469c9d3603aee62c589e
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05344843

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