Sodium Carbonate → HCID 85650986, 화합물

반응식

O=[C:2]([CH3:8])[CH2:3][CH2:4][CH2:5][C:6]#[N:7].Cl.[NH2:10][OH:11].C(=O)([O-])[O-].[Na+].[Na+]>>[N:10](=[C:2]([CH3:8])[CH2:3][CH2:4][CH2:5][C:6]#[N:7])[OH:11]

참가 물질

반응물 3

HCID 10340Sodium Carbonate

HCID 82611Hexanenitrile, 5-oxo-

HCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 85650986HCID 85650986, 화합물

실험 절차

Chem. Ber. 1966, 3387 to 3389 discloses the preparation of 1,5-diaminohexane from 5-oxocapronitrile. In this process, 1,5-diaminohexane is only obtained via the oxime intermediate by first reacting 5-oxocapronitrile with hydroxylamine hydrochloride in the presence of anhydrous sodium carbonate to give 5-oximinocapronitrile, which is subsequently reacted with lithium aluminum hydride to give the diamine; the overall yield is 42%. According to the authors, direct reductive amination of 5-oxocapronitrile gives the cyclization product, 2-methylpiperidine.

출처 및 근거

ORD 기록: ord-1f66391739bf45c79c3eea5a1522f43d
출처 데이터셋: uspto-grants-1994_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05344983

반응 노트

불러오는 중…