Hydrochloric Acid → N-Methyl-6-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yloxy)-3-pyridinecarboxamide

HRID 222655노트

반응식

HRID 222655 반응식
[CH3:1][NH:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]([O:11][C:12]2[CH:29]=[CH:28][C:15]3[CH2:16][CH2:17][N:18](C(OC(C)(C)C)=O)[CH2:19][CH2:20][C:14]=3[CH:13]=2)=[N:9][CH:10]=1)=[O:4].Cl>O1CCOCC1>[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([O:11][C:12]2[CH:29]=[CH:28][C:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20][C:14]=3[CH:13]=2)=[CH:7][CH:6]=1)=[O:4]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 592579286-[(3-Boc-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)oxy]-N-methylnicotinamide

생성물 1

HCID 57440288N-Methyl-6-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yloxy)-3-pyridinecarboxamide

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

1,1-Dimethylethyl 7-({5-[(methylamino)carbonyl]-2-pyridinyl}oxy)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (D39) (3.98 g, 10 mmol) was dissolved in dioxane (40 ml) and treated with a solution of 4M hydrogen chloride in dioxane (35 ml). The reaction mixture was allowed to stir at room temperature for 6 hours and then concentrated in vacuo to afford the title compound (D40); MS (ES+) m/e 298 [M+H]+.

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-def8c2ff55964ad4b66e99f3047adbca
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207331B2

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