Water → (4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

HRID 2227098노트

반응식

HRID 2227098 반응식
S([C:5]1[CH:11]=[CH:10][C:8]([CH3:9])=[CH:7][CH:6]=1)([O-])(=O)=O.[C-:12]#[N:13].[K+].O>CS(C)=O>[CH3:9][C:8]([CH3:10])=[CH:7][CH2:6][CH2:5][C:5]1[CH2:11][CH2:10][CH:8]([CH2:9][C:12]#[N:13])[CH2:7][CH:6]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 9032Potassium CyanideHCID 85570p-Toluenesulfonate

생성물 1

HCID 18471789(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
100 °C

실험 절차

To a solution of tosylate 1H (R=4-Methyl-3-pentenyl) (20 g) in dimethylsulfoxide (178 mL) is added potassium cyanide (19.4 g). The reaction mixture is heated to 100° C., and the reaction mixture is stirred at that temperature for three hours. The reaction mixture is cooled to room temperature, added to water (300 mL), and extracted with hexane. The combined organic layers are dried over magnesium sulfate and the solution is concentrated in vacuo.

후처리

  1. temperatureThe reaction mixture is cooled to room temperature
  2. extractionextracted with hexane
  3. dry with materialThe combined organic layers are dried over magnesium sulfate
  4. concentrationthe solution is concentrated in vacuo

출처 및 근거

ORD 기록
ord-433844a784894642a04da8257ead6d84
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06413448B1

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