Hydrochloric Acid → 4-Methoxyphenyl (4-(4-methyl-3-pentenyl)-3-cyclohexenyl)methyl ketone

HRID 2227101노트

반응식

HRID 2227101 반응식
[CH3:1][C:2]([CH3:16])=[CH:3][CH2:4][CH2:5][C:6]1[CH2:11][CH2:10][CH:9]([CH2:12][C:13](Cl)=[O:14])[CH2:8][CH:7]=1.[C:17]1([O:23][CH3:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.Cl>ClCCl>[CH3:1][C:2]([CH3:16])=[CH:3][CH2:4][CH2:5][C:6]1[CH2:11][CH2:10][CH:9]([CH2:12][C:13]([C:20]2[CH:21]=[CH:22][C:17]([O:23][CH3:24])=[CH:18][CH:19]=2)=[O:14])[CH2:8][CH:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 7519AnisoleHCID 18471799(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetyl chloride

생성물 1

HCID 867582894-Methoxyphenyl (4-(4-methyl-3-pentenyl)-3-cyclohexenyl)methyl ketone

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of acid chloride 2C (R=4-Methyl-3-pentenyl) (10 g) in anhydrous dichloromethane (100 mL) is added dropwise to a mixture of ferric chloride (7.8 g) and anisole 2D (4.5 g) in dichloromethane (175 mL), cooled in an ice/ethanol bath. The resulting mixture is gradually warmed to room temperature and stirred overnight. The mixture is poured into 25% HCl (150 mL) and stirred for 30 minutes. The aqueous layer is extracted with dichloromethane, and the combined organic layers are sequentially washed with water, sodium bicarbonate, and water, then dried over magnesium sulfate. The solution is concentrated in vacuo.

후처리

  1. temperaturecooled in an ice/ethanol bath
  2. stirringstirred for 30 minutes
  3. extractionThe aqueous layer is extracted with dichloromethane
  4. washthe combined organic layers are sequentially washed with water, sodium bicarbonate, and water
  5. dry with materialdried over magnesium sulfate
  6. concentrationThe solution is concentrated in vacuo

출처 및 근거

ORD 기록
ord-e3313ea46cd7402aa009ca69600977fe
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06413448B1

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