Water → 4-(3-Bromopropyl)phenol

HRID 2227105노트

반응식

HRID 2227105 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10]O)=[CH:4][CH:3]=1.[Br:12]C(Br)(Br)Br.O>ClCCl>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][Br:12])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 11205Carbon tetrabromideHCID 824523-(4-Hydroxyphenyl)propanol

생성물 1

HCID 148170364-(3-Bromopropyl)phenol

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 3-(4-hydroxyphenyl)-1-propanol 3A (4.0 g) and tripohenylphosphine (7.96 g) in anhydrous dichloromethane (77 mL), cooled to 0° C., is added, dropwise, a solution of tetrabromomethane (9.59 g) in anhydrous dichloromethane (15.4 mL). The reaction mixture gradually warmed to room temperature and allowed to stir overnight. The solution is then poured into water and extracted with ethyl acetate. The combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo.

후처리

  1. additionis added
  2. extractionextracted with ethyl acetate
  3. washThe combined organic layers are washed with brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationThe solution is concentrated in vacuo

출처 및 근거

ORD 기록
ord-ddc232abfd544438b4acbac4d5921aaa
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06413448B1

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