Triphenylphosphine → [3-(4-[2-Tetrahydropyranyloxy]phenyl)propyl]triphenylphosphonium bromide

HRID 2227107노트

반응식

HRID 2227107 반응식
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][Br:17])=[CH:10][CH:9]=1.[C:18]1([P:24]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CN(C)C=O>[Br-:17].[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][P+:24]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 184717901-(4'-(2-Tetrahydropyranyloxy)phenyl)-3-bromopropane

생성물 1

HCID 18471791[3-(4-[2-Tetrahydropyranyloxy]phenyl)propyl]triphenylphosphonium bromide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

To a solution of 1-(4′-(2-tetrahydropyranyloxy)phenyl)-3-bromopropane 3C (4.2 g) in anhydrous dimethylformamide (11.3 mL) is added triphenylphosphine (6.12 g). The reaction mixture is stirred under nitrogen at 100° C. overnight. The reaction mixture is then cooled to room temperature. The white precipitate is filtered and washed with ethyl acetate, then dried under vacuum.

후처리

  1. temperatureThe reaction mixture is then cooled to room temperature
  2. filtrationThe white precipitate is filtered
  3. washwashed with ethyl acetate
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-b72bb3d0d75f46bfb1032efeb930efd4
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06413448B1

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