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Water → 1-Methyl-2-[(4-amidinophenyl)thiomethyl]benzimidazol-5-yl-carboxylic acid-N-(n-propyl)-N-(2-hydroxycarbonylethyl)amide hydrochloride

HRID 2227634
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HRID 2227634 반응식
[ClH:1].[CH2:2]([N:5]([CH2:29][CH2:30][C:31]([O:33]CC)=[O:32])[C:6]([C:8]1[CH:28]=[CH:27][C:11]2[N:12]([CH3:26])[C:13]([CH2:15][S:16][C:17]3[CH:22]=[CH:21][C:20]([C:23](=[NH:25])[NH2:24])=[CH:19][CH:18]=3)=[N:14][C:10]=2[CH:9]=1)=[O:7])[CH2:3][CH3:4].[OH-].[Na+].O>C(O)C>[ClH:1].[CH2:2]([N:5]([CH2:29][CH2:30][C:31]([OH:33])=[O:32])[C:6]([C:8]1[CH:28]=[CH:27][C:11]2[N:12]([CH3:26])[C:13]([CH2:15][S:16][C:17]3[CH:22]=[CH:21][C:20]([C:23](=[NH:24])[NH2:25])=[CH:19][CH:18]=3)=[N:14][C:10]=2[CH:9]=1)=[O:7])[CH2:3][CH3:4]
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참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 184124111-methyl-2-[(4-amidinophenyl)thiomethyl]benzimidazol-5-yl-carboxylic acid-N-(n-propyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride

생성물 1

HCID 184126651-Methyl-2-[(4-amidinophenyl)thiomethyl]benzimidazol-5-yl-carboxylic acid-N-(n-propyl)-N-(2-hydroxycarbonylethyl)amide hydrochloride

시약·촉매·용매 1

HCID 702
Ethanol
용매

실험 절차

0.52 g (1.0 mmol) of 1-Methyl-2-[(4-amidinophenyl)thiomethyl]benzimidazol-5-yl-carboxylic acid-N-(n-propyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride was dissolved in 15 ml ethanol, mixed with 5 ml of 2N sodium hydroxide solution and stirred for 2 hours at room temperature. Then 5 ml of water were added, the alcohol was distilled off, and it was acidified with concentrated hydrochloric acid. The water was distilled off in vacuo, and the crude product was taken up in 5 ml of ethanol and filtered to remove the insoluble sodium chloride. After the solvent had been distilled off, the title compound was obtained as a white solid.

후처리

  1. distillationthe alcohol was distilled off
  2. distillationThe water was distilled off in vacuo
  3. filtrationfiltered
  4. customto remove the insoluble sodium chloride
  5. distillationAfter the solvent had been distilled off

출처 및 근거

ORD 기록
ord-20d04955948d4ad68cffa8226f9a3d46
출처 데이터셋
uspto-grants-2002_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06414008B1

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