N-bromobutanimide → Methyl 4-(5-bromothiophen-2-yl)butanoate

HRID 2227855노트

반응식

HRID 2227855 반응식
C1C(=O)N([Br:8])C(=O)C1.[CH3:9][O:10][C:11](=[O:20])[CH2:12][CH2:13][CH2:14][C:15]1[S:16][CH:17]=[CH:18][CH:19]=1.C(OP(CCCCC1C=CSC=1Br)(=O)OCC)C>>[CH3:9][O:10][C:11](=[O:20])[CH2:12][CH2:13][CH2:14][C:15]1[S:16][C:17]([Br:8])=[CH:18][CH:19]=1

참가 물질

4

반응물 3

HCID 67184N-bromobutanimideHCID 1407664-(2-Thienyl)butanoic acid methyl esterHCID 18680339HCID 18680339, 화합물

생성물 1

HCID 18474982Methyl 4-(5-bromothiophen-2-yl)butanoate수율 90%

실험 절차

The NBS bromination of 1b according to the procedure outlined for the preparation of 2a gave >90% yield of 2b as a colorless oil. b.p.: 138° C. at 0.15 mmHg. 1H NMR (250 MHz, 25° C., CDCl3): δ6.82 (d, 1H, Ar—H), 6.52 (d, 1H, Ar—H), 3.64 (s, 3H, OCH3), 2.79 (t, 2H, CH2CO2Me), 2.33 (t, 2H, Ar—CH2), 1.93 (tt, 2H, CH2CH2CH2).

출처 및 근거

ORD 기록
ord-7f1133073b42433986eb87501c6dd032
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06414164B1

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