Acetic Acid → Ethyl 3-anilinobut-2-enoate

HRID 222788

반응식

HRID 222788 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8]([O:14][CH2:15][CH3:16])(=[O:13])[CH2:9][C:10]([CH3:12])=O.C(O)(=O)C>>[NH:1]([C:10]([CH3:12])=[CH:9][C:8]([O:14][CH2:15][CH3:16])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 176Acetic AcidHCID 6115AnilineHCID 8868Ethyl Acetoacetate

생성물 1

HCID 94928Ethyl 3-anilinobut-2-enoate

실험 절차

The title compound is commercially available. A mixture of aniline (9.785 mL, 107.4 mmol), ethyl acetoacetate (13.69 mL, 107.4 mmol), and acetic acid (0.6 mL, 10 mmol) was stirred at ambient temperature overnight. It was partitioned between heptane (50 mL) and sat. aq. NaHCO3 solution (50 mL). The organic layer was dried and evaporated to give the title compound of >90% purity that was used in the next steps without further purification.

후처리

  1. customIt was partitioned between heptane (50 mL) and sat. aq. NaHCO3 solution (50 mL)
  2. customThe organic layer was dried
  3. customevaporated

출처 및 근거

ORD 기록
ord-1e6b975239ce4332973365ad3d45bb4c
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207347B2

연결된 노트

불러오는 중…