Formaldehyde → 5-Methoxy-2-methylindan-1-one

HRID 2228345

반응식

HRID 2228345 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7][CH2:6]2.C=O.[OH-].[K+].[CH3:17]CCCCC>C(O)C.[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[Fe].C(OC(=O)C)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH:7]([CH3:17])[CH2:6]2

참가 물질

8

반응물 4

HCID 712FormaldehydeHCID 8058HexaneHCID 14797Potassium HydroxideHCID 787875-Methoxyindan-1-one

생성물 1

HCID 122904905-Methoxy-2-methylindan-1-one수율 44%

시약·촉매·용매 3

HCID 518773Pentacarbonyliron(0)촉매HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

5-Methoxy indanone was treated with aqueous formaldehyde in the presence of iron pentacarbonyl and KOH in ethanol according to G. Cainelli et. al., Tetrahedron Letters 27, 2491 (1973). After chromatography (hexane:ethylacetate=7:3) over SiO2, a 44% yield of white crystals was obtained (m.p. 73-76° C.).

출처 및 근거

ORD 기록
ord-25fd0c8a62c34b399dc7840abb978e0e
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06416746B1

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