홈 MCP 워크벤치 Skills

홈 워크벤치 알림 마이페이지

llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0

홈
반응

Benzoic Acid → Cyano-(6-methoxy-3,3-dimethyl-5-prop-2-ynyloxy-indan-1-ylidene)-acetic acid ethyl ester

HRID 2228352

인쇄 미리보기

반응식

HRID 2228352 반응식

[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH3:14])([CH3:13])[CH2:8][C:9]2=O)=[CH:5][C:4]=1[O:15][CH2:16][C:17]#[CH:18].[CH3:19][CH2:20][O:21][C:22]([CH2:24][C:25]#[N:26])=[O:23].N1CCCC1.C(O)(=O)C1C=CC=CC=1>C1(C)C(C)=CC=CC=1.O>[CH2:20]([O:21][C:22](=[O:23])[C:24]([C:25]#[N:26])=[C:9]1[C:10]2[C:6](=[CH:5][C:4]([O:15][CH2:16][C:17]#[CH:18])=[C:3]([O:2][CH3:1])[CH:11]=2)[C:7]([CH3:14])([CH3:13])[CH2:8]1)[CH3:19]

참가 물질 실험 절차 후처리 출처 및 근거 반응 노트

참가 물질

7

반응물 4

HCID 243Benzoic Acid

HCID 7764Ethyl cyanoacetate

HCID 31268Pyrrolidine

HCID 184695826-Methoxy-3,3-dimethyl-5-prop-2-ynyloxy-indan-1-one

생성물 1

HCID 53867743Cyano-(6-methoxy-3,3-dimethyl-5-prop-2-ynyloxy-indan-1-ylidene)-acetic acid ethyl ester수율 20.6%

시약·촉매·용매 2

HCID 962

Water

용매

HCID 7237O-Xylene용매

실험 절차

The above 6-methoxy-3,3-dimethyl-5-prop-2-ynyloxy-indan-1-one (2.44 g) was treated with 1.13 g of ethyl cyano acetate in the presence of 0.1 equivalents of pyrrolidine and benzoic acid in 20 ml of xylene. The reaction mixture was refluxed for 30 hours with simultaneous separation of water. Then, the cold reaction mixture was washed with water, concentrated and chromatographed in hexane/ethyl acetate through SiO2 to yield 0.7 g of yellow crystals. m.p. 132-136° C. UV 362 nm (ε=23′222), MS: 339(M+), 324, 300 (100%).

후처리

customThen, the cold reaction mixture
washwas washed with water
concentrationconcentrated
customchromatographed in hexane/ethyl acetate through SiO2

출처 및 근거

ORD 기록: ord-b4834fbdde0e482d9b81e85d89997b96
출처 데이터셋: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06416746B1

반응 노트

불러오는 중…

이 페이지에서참가 물질 실험 절차 후처리 출처 및 근거 반응 노트