Hydrazine hydrate (1:1) → 2-hydrazono-1-phenylpropan-1-one O-methyl oxime

HRID 2229132노트

반응식

HRID 2229132 반응식
[CH3:1][O:2][N:3]=[C:4]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5](=O)[CH3:6].O.[NH2:15][NH2:16]>C(O)C>[CH3:1][O:2][N:3]=[C:4]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5](=[N:15][NH2:16])[CH3:6]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 539446061-phenylpropane-1,2-dione 1-(O-methyl oxime)

생성물 1

HCID 572718472-hydrazono-1-phenylpropan-1-one O-methyl oxime수율 56%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.5 g (0.014 mol) of 1-phenylpropane-1,2-dione 1-(O-methyl oxime) are heated at 60° C. in 20 ml of ethanol with 1.45 g (0.029 mol) of hydrazine hydrate for 1 hour. The reaction mixture is poured onto water and extracted with diethyl ether, the organic phase is dried over sodium sulphate and the solvent is distilled off in vacuo. The residue is stirred with diethyl ether and the crystals are filtered off. 1.5 g (55.6% of theory) of 2-hydrazono-1-phenylpropan-1-one O-methyl oxime of melting point 132° C. are obtained.

후처리

  1. additionThe reaction mixture is poured onto water
  2. extractionextracted with diethyl ether
  3. dry with materialthe organic phase is dried over sodium sulphate
  4. distillationthe solvent is distilled off in vacuo
  5. filtrationthe crystals are filtered off

출처 및 근거

ORD 기록
ord-f451d3764de9463eaa794004fca71fa6
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06420362B1

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