Sodium borohydride → Ethyl2-(1,2-dihydro-1-acenaphthylenyl)acetate

HRID 2230265노트

반응식

HRID 2230265 반응식
[BH4-].[Na+].[CH2:3]([O:5][C:6](=[O:20])[CH:7]=[C:8]1[C:18]2=[C:19]3[C:14](=[CH:15][CH:16]=[CH:17]2)[CH:13]=[CH:12][CH:11]=[C:10]3[CH2:9]1)[CH3:4]>CO.Cl[Pd]Cl>[CH2:3]([O:5][C:6](=[O:20])[CH2:7][CH:8]1[C:18]2=[C:19]3[C:14](=[CH:15][CH:16]=[CH:17]2)[CH:13]=[CH:12][CH:11]=[C:10]3[CH2:9]1)[CH3:4]

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 70179131Ethyl2-(1,2-dihydro-1-acenaphthylenylidene)acetate

생성물 1

HCID 13715672Ethyl2-(1,2-dihydro-1-acenaphthylenyl)acetate

시약·촉매·용매 2

HCID 24290Palladium Chloride촉매HCID 887Methanol용매2회

실험 절차

55 mg of PdCl2 in 5 ml of methanol are treated with 25 mg of sodium borohydride. After 15 minutes' stirring, the compound obtained in Step B (1 g, 4.20.10−3 mol), diluted with methanol (25 ml), is added. The mixture is purged with argon and placed under a hydrogen atmosphere. After 2 hours 30 minutes' hydrogenation, the reaction mixture is filtered over Celite, rinsed and then evaporated under reduced pressure.

후처리

  1. additionis added
  2. customThe mixture is purged with argon
  3. waitAfter 2 hours 30 minutes' hydrogenation
  4. filtrationthe reaction mixture is filtered over Celite
  5. washrinsed
  6. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-455c973d4abd4c9dbc62bc0345c0c13c
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06423870B1

반응 노트

불러오는 중…