Hydrochloric Acid → 2-Methoxy-5-methYlsulfinylbenzoic acid
반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([S:13]([CH3:15])=[O:14])=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[K+].Cl>ClCCl>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([S:13]([CH3:15])=[O:14])=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]참가 물질
5
실험 절차
Combine methyl 2-methoxy-5-methylsulfinylbenzoate (2.37 g, 12.0 mmol) and a 1 M aqueous solution of potassium hydroxide (13 mL, 13 mmol). Heat to reflux. After 2 hours, cool to ambient temperature and adjust the pH to about 2 using a 1 M aqueous hydrochloric acid (14.5 mL, 14.5 mmol). Evaporate in vacuo to give a solid. Combine the solid and dichloromethane and stir. Decant the solvent and add more dicliloromethane. Again decant and combine with the first decantate, dry over Na2SO4, filter, and evaporate in vacuo to to give the title compound: mp; 114-116° C.
후처리
- temperatureHeat to reflux
- customEvaporate in vacuo
- customto give a solid
- customDecant the solvent
- additionadd more dicliloromethane
- customAgain decant
- dry with materialdry over Na2SO4
- filtrationfilter
- customevaporate in vacuo
출처 및 근거
- ORD 기록
- ord-3bc802bb233041aabd0107d7db0ff7b3
- 출처 데이터셋
- uspto-grants-2002_07
- 특허 번호
- US06423704B1
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