Lithium Hydroxide → 3-(1H-tetrazol-1-yl)benzoic acid
반응식
[N:1]1([C:6]2[CH:7]=[C:8]([CH:14]=[CH:15][CH:16]=2)[C:9]([O:11]CC)=[O:10])[CH:5]=[N:4][N:3]=[N:2]1.[OH-].[Li+]>O1CCCC1.O>[N:1]1([C:6]2[CH:7]=[C:8]([CH:14]=[CH:15][CH:16]=2)[C:9]([OH:11])=[O:10])[CH:5]=[N:4][N:3]=[N:2]1참가 물질
4
실험 절차
Combine ethyl 3-(1H-tetrazol-1-yl)benzoate (4.93 g, 22.6 mmol) and tetrahydrofuran/water (100 mL/25 mL). Add lithium hydroxide (1.9 g, 45.2 mmol) and heat to reflux. After 2 hours, cool to ambient temperature and extract the reaction mixture five times with a 1 M aqueous sodium hydroxide solution. Combine the aqueous layers and extract with ethyl acetate. Acidify the aqueous layers with a 1 M aqueous hydrochloric acid solution (pH about 1) to give a solid. Collect the solid by filtration to give the title compound.
후처리
- extractionextract the reaction mixture five times with a 1 M aqueous sodium hydroxide solution
- extractionextract with ethyl acetate
- customto give a solid
- customCollect the solid
- filtrationby filtration
출처 및 근거
- ORD 기록
- ord-fb5589c2fd294a4689a73f602d7e9bca
- 출처 데이터셋
- uspto-grants-2002_07
- 특허 번호
- US06423704B1
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