1-Phenylpiperazine → 6-methoxy-7-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one

HRID 22308

반응식

HRID 22308 반응식
ClCCCO[C:6]1[C:7](=[O:18])[O:8][C:9]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][C:10]=2[CH:11]=1.[C:19]1([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C([O-])(=O)/[CH:32]=[CH:33]/[C:34]([O-])=[O:35]>CC(OC)(C)C.C(O)(C)C>[CH3:17][O:16][C:13]1[C:14]([O:35][CH2:34][CH2:33][CH2:32][N:28]2[CH2:29][CH2:30][N:25]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:26][CH2:27]2)=[CH:15][C:9]2[O:8][C:7](=[O:18])[CH:6]=[CH:11][C:10]=2[CH:12]=1

참가 물질

6

반응물 3

HCID 70961-PhenylpiperazineHCID 5460307FumarateHCID 867487533-(chloropropoxy)-6-methoxy-2H-1-benzopyran-2-one

생성물 1

HCID 199276746-methoxy-7-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one수율 94%

시약·촉매·용매 2

HCID 3776Isopropanol용매2회HCID 15413tert-Butyl methyl ether용매2회

실험 절차

Method B (9 h at 70° C.); starting materials: 7-[3-(chloropropoxy)-6-methoxy-2H-1-benzopyran-2-one (see example 69) and 1-phenylpiperazine; yield 94%; fusion point 82° to 83° (from isopropanol and TBME). Fumarate: method E; yield 94%; fusion point 168° to 170° C. (from isopropanol and TBME).

후처리

  1. customMethod B (9 h at 70° C.)

출처 및 근거

ORD 기록
ord-6847489470b44f3c997251298a9f7a2a
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428038

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