Water → Sulazuril

HRID 2231187노트

반응식

HRID 2231187 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N:20]2[C:25](=[O:26])[NH:24][C:23](=[O:27])[CH2:22][NH:21]2)[CH:5]=[C:6]([Cl:19])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][CH:10]=1.[CH3:28]I.O>CN1CCCC1=O>[Cl:1][C:2]1[CH:3]=[C:4]([N:20]2[C:25](=[O:26])[NH:24][C:23](=[O:27])[CH2:22][N:21]2[CH3:28])[CH:5]=[C:6]([Cl:19])[C:7]=1[O:8][C:9]1[CH:10]=[CH:11][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:13][CH:14]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6328Methyl iodide2회HCID 13823230HCID 13823230, 화합물

생성물 1

HCID 65904Sulazuril

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

1 g of 2-[3,5-dichloro-4-(4-methylsulfonylphenoxy)phenyl]hexahydro-1,2,4-triazine-3,5-dione in 10 ml of N-methylpyrrolidone was heated at 140° to 160° C. with 10 ml of methyl iodide for four hours and, after addition of a further 10 ml of methyl iodide, for a further three hours. After the mixture had been cooled, water was added and an oil separated out, which slowly became solid and was recrystallized from methanol with the addition of active charcoal. Melting point 223° C.

후처리

  1. temperatureAfter the mixture had been cooled
  2. customan oil separated out
  3. customwhich slowly became solid and was recrystallized from methanol with the addition of active charcoal

출처 및 근거

ORD 기록
ord-c43a07bb364c40ffba0e6dd334fe3871
출처 데이터셋
uspto-grants-1988_11
특허 번호
US04782056

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