Hydrochloric Acid → 1-Chloro-2,3-dihydro-1H-indene

HRID 223120

반응식

HRID 223120 반응식
[CH:1]1(O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.N#N.[ClH:13]>C1CCCCC1>[CH:1]1([Cl:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 947NitrogenHCID 228191-Indanol

생성물 1

HCID 944651-Chloro-2,3-dihydro-1H-indene

시약·촉매·용매 1

HCID 8078Cyclohexane용매

실험 절차

20 g Indanone (obtained according to Example VIII) is added to a solution of 1.5 molequivalent NaAlH2 (OC2H4OCH3)2 in a mixture of benzene and ether in the course of which the temperature raises to 35° C. Then the reaction mixture is stirred during one hour, poured out into ice and extracted with ether. The solution in ether is washed with NaCl solution, dried and evaporated. The residue is distilled under diminished pressure yielding 15.1 g indanol. B.p. 115° C./1 mm Hg. The indanol is dissolved in 100 ml cyclohexane and during 30 min. gaseous HCl is introduced followed by N2 to remove the excess of HCl. The reaction mixture is evaporated and the residue is distilled under diminished pressure yielding 12.9 g indanyl chloride. B.p. 95° C./1 mm Hg.

후처리

  1. additionis introduced
  2. customto remove the excess of HCl
  3. customThe reaction mixture is evaporated
  4. distillationthe residue is distilled under diminished pressure

출처 및 근거

ORD 기록
ord-aaf69d7fe57a46a49d21ea27897a87b6
출처 데이터셋
uspto-grants-1982_10
특허 번호
US04352748

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