Acetyl chloride → 1-Acetyl-4-phenylimidazole

HRID 2231253노트

반응식

HRID 2231253 반응식
[C:1]1([C:7]2[N:8]=[CH:9][NH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].[C:14](Cl)(=[O:16])[CH3:15]>O1CCCC1>[C:14]([N:10]1[CH:11]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:8]=[CH:9]1)(=[O:16])[CH3:15]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 24758Sodium hydrideHCID 178418822HCID 178418822, 화합물

생성물 1

HCID 108214021-Acetyl-4-phenylimidazole

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4-phenylimidazole in 40 ml of tetrahydrofuran was added portionwise 1.66 g of 50% sodium hydride. After stirring for 20 minutes, 2.46 ml of acetyl chloride was added over 10 minutes and the reaction mixture allowed to stir overnight at room temperature. The reaction was filtered and the filtrate concentrated to give 4 g of crude product which was purified by chromatographing on 150 g of silica gel using 5% methanol in chloroform as eluent, 2.88 g.

후처리

  1. stirringto stir overnight at room temperature
  2. filtrationThe reaction was filtered
  3. concentrationthe filtrate concentrated

출처 및 근거

ORD 기록
ord-912abe7593c647b99ca32f4469d7bc09
출처 데이터셋
uspto-grants-1988_11
특허 번호
US04782050

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