Acetic Anhydride → 4'-Acetoxy-5-hydroxy-3,3',7-trimethoxyflavone

HRID 223127

반응식

HRID 223127 반응식
[OH:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]2[O:7][C:8]3[C:13]([C:14](=[O:18])[C:15]=2[O:16][CH3:17])=[C:12]([OH:19])[CH:11]=[C:10]([O:20][CH3:21])[CH:9]=3)=[CH:4][C:3]=1[O:24][CH3:25].[C:26]([O-])(=[O:28])[CH3:27].[Na+].C(OC(=O)C)(=O)C>>[C:26]([O:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]2[O:7][C:8]3[C:13]([C:14](=[O:18])[C:15]=2[O:16][CH3:17])=[C:12]([OH:19])[CH:11]=[C:10]([O:20][CH3:21])[CH:9]=3)=[CH:4][C:3]=1[O:24][CH3:25])(=[O:28])[CH3:27]

참가 물질

4

반응물 3

HCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 5281677Pachypodol

생성물 1

HCID 205225554'-Acetoxy-5-hydroxy-3,3',7-trimethoxyflavone수율 90%

반응 조건

온도
100 °C

실험 절차

A mixture of 250 mg of 4',5-dihydroxy-3,3',7-trimethoxyflavone, 60 mg of sodium acetate and 70 mg of acetic anhydride was heated at 100° C. for 2 hours. The reaction mixture was evaporated under reduced pressure, and the residue was extracted with 30 ml of chloroform. Removal of the solvent from the extract and subsequent recrystallization of the residue from methanol gave 250 mg (90% yield) of 4'-acetoxy-5-hydroxy-3,3',7-trimethoxyflavone as yellow crystals: m.p. 168°-169° C.

후처리

  1. customThe reaction mixture was evaporated under reduced pressure
  2. extractionthe residue was extracted with 30 ml of chloroform
  3. customRemoval of the solvent from the
  4. extractionextract
  5. customsubsequent recrystallization of the residue from methanol

출처 및 근거

ORD 기록
ord-1f8793b850b9462e8558abd9f4b2a09e
출처 데이터셋
uspto-grants-1982_10
특허 번호
US04352792

연결된 노트

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