Hydrochloric Acid → 2-Hydroxybenzo(b)thiophene-3-carboxamide

반응식

C(N[C:5]1[S:9][C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[C:6]=1[C:14]#[N:15])(=O)C.C([OH:18])C.Cl.[OH2:20]>>[OH:20][C:5]1[S:9][C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[C:6]=1[C:14]([NH2:15])=[O:18]

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 962Water2회

HCID 21286564N-(3-Cyano-1-benzothiophen-2-yl)acetamide

생성물 1

HCID 142579342-Hydroxybenzo(b)thiophene-3-carboxamide

실험 절차

A mixture of 2-acetamido-3-cyanobenzo(b)thiophene (2.2 g, 0.01 m), ethanol (25 ml), water (15 ml) and concentrated hydrochloric acid (25 ml) is heated under reflux for 12 hours. The reaction mixture is diluted with water, aged and filtered to yield 2-hydroxybenzo(b)thiophene-3-carboxamide.