Sodium Hydroxide → 3-[4-(4-Oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid

HRID 2231366노트

반응식

HRID 2231366 반응식
F[C:2]1[CH:15]=[CH:14][C:5]([C:6]([CH:8]([CH3:13])[CH2:9][C:10]([OH:12])=[O:11])=[O:7])=[CH:4][CH:3]=1.[OH:16][C:17]1[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=1.[OH-].[Na+]>O>[O:16]=[C:17]1[CH:22]=[CH:21][N:20]([C:2]2[CH:15]=[CH:14][C:5]([C:6]([CH:8]([CH3:13])[CH2:9][C:10]([OH:12])=[O:11])=[O:7])=[CH:4][CH:3]=2)[CH:19]=[CH:18]1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 124495243-(4-Fluorobenzoyl)butanoic acidHCID 178418642HCID 178418642, 화합물

생성물 1

HCID 99477483-[4-(4-Oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A solution of 3-(4-fluorobenzoyl)butanoic acid (885 g), 4-hydroxypyridine (663 g) and sodium hydroxide (453 g) in water (2.2 liters) was stirred under reflux for 24 hours. The reaction mixture was cooled, diluted with water (10 liters) and filtered through diatomaceous earth. The filtrate was acidified to pH 3 with concentrated hydrochloric acid to afford as a cream solid 3-[4-(4-oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid, 1127 g (94%), m.p. 251°-254° C.

후처리

  1. temperatureunder reflux for 24 hours
  2. temperatureThe reaction mixture was cooled
  3. filtrationfiltered through diatomaceous earth

출처 및 근거

ORD 기록
ord-9315b0928757414090e98232b2951f49
출처 데이터셋
uspto-grants-1988_11
특허 번호
US04782159

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