Sulfuric Acid → 7-Chloro-4-methyl-8-nitroisoquinoline

HRID 223145

반응식

HRID 223145 반응식
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[N+:18]([O-])([O-:20])=[O:19].[K+]>>[Cl:1][C:2]1[C:11]([N+:18]([O-:20])=[O:19])=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 1118Sulfuric Acid2회HCID 24434Potassium NitrateHCID 205232237-Chloro-4-methylisoquinoline

생성물 1

HCID 205232187-Chloro-4-methyl-8-nitroisoquinoline

실험 절차

A mixture of 17.7 g. (0.1 mole) of 7-chloro-4-methylisoquinoline and 100 ml. of concentrated sulfuric acid is treated with 10 g. (0.1 mole) of potassium nitrate dissolved in 150 ml. of concentrated sulfuric acid. The mixture is stirred for one hour, quenched on ice, made alkaline with ammonium hydroxide and filtered to yield 7-chloro-4-methyl-8-nitroisoquinoline.

후처리

  1. additionA mixture of 17.7 g
  2. customquenched on ice
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-153a648d1b2f46eea8d8e5555ee8287b
출처 데이터셋
uspto-grants-1982_10
특허 번호
US04352809

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