Hydrochloric Acid → 7-Methoxy-1-methylisoquinoline

HRID 223148노트

반응식

HRID 223148 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:25]=[CH:26][CH:27]=1)[CH:6]([N:8]([CH2:19][CH:20](OC)OC)S(C1C=CC(C)=CC=1)(=O)=O)[CH3:7].O1CCOCC1.Cl>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:25]([CH:20]=[CH:19][N:8]=[C:6]2[CH3:7])=[CH:26][CH:27]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 20523222HCID 20523222, 화합물

생성물 1

HCID 159337467-Methoxy-1-methylisoquinoline

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 39.3 g. (0.1 mole) of 3-methoxy-α-methyl-N-(2,2-dimethoxyethyl)-N-tosyl-benzylamine, one liter of dioxane and 80 ml. of 6 N hydrochloric acid is refluxed for six hours and allowed to stand for sixteen hours. The mixture is poured into two liters of water and extracted with ether. The aqueous phase is made alkaline with concentrated ammonium hydroxide and extracted with chloroform. The chloroform extract is washed, dried and evaporated to yield 7-methoxy-1-methylisoquinoline.

후처리

  1. additionA mixture of 39.3 g
  2. waitto stand for sixteen hours
  3. extractionextracted with ether
  4. extractionextracted with chloroform
  5. extractionThe chloroform extract
  6. washis washed
  7. customdried
  8. customevaporated

출처 및 근거

ORD 기록
ord-bae13efb8328448aab3dd8acd161d615
출처 데이터셋
uspto-grants-1982_10
특허 번호
US04352809

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