Hydrogen Bromide → 113884-76-7

반응식

Cl.C[O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[O:14]C)[CH:10]=[N:9][CH:8]=[CH:7]2.[BrH:16]>>[BrH:16].[OH:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[OH:14])[CH:10]=[N:9][CH:8]=[CH:7]2

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 212868646,7-Dimethoxyisoquinoline hydrochloride

생성물 1

HCID 135736659113884-76-7수율 97.6%

실험 절차

63.4 g (0.28 mol) of 6,7-dimethoxyisoquinoline hydrochloride was dissolved in 630 ml of 47% hydrobromic acid, and the mixture was refluxed for 24 hours under stirring in nitrogen atmosphere. The reaction mixture was allowed to stand still under cooling with ice. The crystals formed were collected by filtration and washed with cold water and acetone. They were dried in air overnight and then dried at a temperature of from 90° to 95° C. for 6 hours to obtain 66.4 g (yield: 97.6%) of the above identified compound.

후처리

temperaturethe mixture was refluxed for 24 hours
temperatureunder cooling with ice
customThe crystals formed
filtrationwere collected by filtration
washwashed with cold water and acetone
customThey were dried in air overnight
customdried at a temperature of from 90° to 95° C. for 6 hours
customto obtain 66.4 g (yield: 97.6%) of the

출처 및 근거

ORD 기록: ord-b1790ec008744d5cac8ad4aa2ffd039b
출처 데이터셋: uspto-grants-1988_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04782155

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