tert-Butyl methyl ether → 6-(cyclopentyloxy)-7-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one

HRID 22317

반응식

HRID 22317 반응식
[CH:1]1([O:6][C:7]2[C:8]([O:18][CH2:19][CH2:20][CH2:21]OS(C)(=O)=O)=[CH:9][C:10]3[O:15][C:14](=[O:16])[CH:13]=[CH:12][C:11]=3[CH:17]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:27]1([CH:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.CC(OC)(C)C.C([O-])(=O)/C=C/C([O-])=O>CC(C)=O.C(O)(C)C>[CH:1]1([O:6][C:7]2[C:8]([O:18][CH2:19][CH2:20][CH2:21][N:36]3[CH2:35][CH2:34][CH:33]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[CH2:38][CH2:37]3)=[CH:9][C:10]3[O:15][C:14](=[O:16])[CH:13]=[CH:12][C:11]=3[CH:17]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

7

반응물 4

HCID 15413tert-Butyl methyl etherHCID 698734-PhenylpiperidineHCID 5460307FumarateHCID 199276356-(cyclo-pentyloxy)-7-[3-(methanesulfonyloxy)propoxy]-2H-1-benzopyran-2-one

생성물 1

HCID 199276916-(cyclopentyloxy)-7-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one수율 48%

시약·촉매·용매 2

HCID 180Acetone용매HCID 3776Isopropanol용매

실험 절차

Method B (30 h at 45° C.); starting materials: 6-(cyclo-pentyloxy)-7-[3-(methanesulfonyloxy)propoxy]-2H-1-benzopyran-2-one (example 72) and 4-phenylpiperidine; yield 48%; fusion point 96°-97° C. (from TBME and isopropanol). Fumarate: method E; yield 83%; fusion point 171°-173° C. (from acetone).

후처리

  1. customMethod B (30 h at 45° C.)

출처 및 근거

ORD 기록
ord-54f2a4b0bf734d449f00a8d39ca228b9
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428038

연결된 노트

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