Hydrochloric Acid → 5-Aminoisothiazole-3,4-dicarbonitrile

HRID 2231960노트

반응식

HRID 2231960 반응식
CN(C)C=[N:4][C:5]1[S:9][N:8]=[C:7]([C:10]#[N:11])[C:6]=1[C:12]#[N:13].C(O)C.Cl>O>[NH2:4][C:5]1[S:9][N:8]=[C:7]([C:10]#[N:11])[C:6]=1[C:12]#[N:13]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 54385684HCID 54385684, 화합물

생성물 1

HCID 212852515-Aminoisothiazole-3,4-dicarbonitrile수율 87%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 45.3 parts of N,N-dimethyl-N'-(3,4-dicyanoisothiazol-5-yl)-formamidine, 400 parts of ethanol and 60 parts of concentrated hydrochloric acid is heated at the boil for 2.5 hours, after which it is introduced into 400 parts of water. The colorless precipitate is filtered off under suction, washed with water and dried to give 28.6 parts (87% of theory) of 5-aminoisothiazole-3,4-dicarbonitrile.

후처리

  1. temperatureis heated at the boil for 2.5 hours
  2. filtrationThe colorless precipitate is filtered off under suction
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-0cb5fe07597141849b590bf460fabdaf
출처 데이터셋
uspto-grants-1988_11
특허 번호
US04785116

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